On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.

In NHW population, the association failed to reach significance after APOE adjustment. 30 Interestingly, the SNPs, including rs2075650, rs71352238, and rs157582, in LD located on TOMM40 showed significant heterogeneity among populations (Table 2 ).

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In the ASN population, the OR was not significant, while AA and NHW showed a highly significant OR and HISP was followed (Figure 2A ).

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The number of replicated DSLs having a nominally significant p value (< 5%) in our cohort was 79 (30.50%).

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