Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy.

At the protein level, Nox4 overexpression at the lower dose (MOI: 25) failed to alter PECAM-1 expression; however, the higher dose (MOI: 50) showed a modest effect of reducing PECAM-1 expression, although the change did not reach statistical significance ( Fig 4B & 4C ).

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