Interplay Between Plasma Glycine and Branched-Chain Amino Acids Contributes to the Development of Hypertension and Coronary Heart Disease.

Absolute causal estimates of the effects of tBCAAs/glycine ratio, defined using all available instruments irrespective of P -gain value, were similar to those obtained for glycine, likely due to the presence of highly significant CPS1 variants in instrument sets of both traits ( Tables S2 and S4 ).

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The level of tBCAAs was a risk factor for CHD, yet this effect did not reach statistical significance in either of the cohorts analyzed (Figure 4 A and 4 B).

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