Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment.

However, our comprehensive analysis, incorporating a 92-plexed panel of inflammatory molecules, consistently revealed a decreasing trend in cytotoxicity-associated proteins, including IL-18R1, CD5, PD-L1 and TNFRSF9, along with two other inflammatory proteins, CX3CL1 and MMP-1, after 6 months of treatment.

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These reductions demonstrated statistical significance via the Wilcoxon signed-rank test but did not reach statistical significance when rigorously accounting for multiple hypothesis testing 51 (“Methods”).

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