Intelligent nanovesicle for remodeling tumor microenvironment and circulating tumor chemoimmunotherapy amplification.

After that, 5-FU release curve from ENP919 nanovesicle was evaluated, and 5-FU showed a trend of continuous release in introduction of MMP-2 enzyme, and even after 24 h, the cumulative release of 5-FU reached 65% (Fig. 2 d).

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During this process, interferon-γ (IFN-γ) from activated T cells will show an increasing trend and play a tumor immunodepression effect via the two ways, i.e., the regulation of the classic first type of major histocompatibility complex (MHC-I) to inhibit natural killer (NK) cells and the inhibition of CD8 + T cells by upregulating non-classical MHC-I molecules Qa-1b [ 22 ].

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