Coding TMB (Methods) was significantly correlated with TMB derived from the whole genome (R = 0.95, p < 2.2 × 10–16, Spearman), and was lower than in our adult cohort (median 1.28 in the pediatric cohort, range: 0.08–7.44), though this did not reach statistical significance ( P = 0.13, Wilcoxon rank sum).
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Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers.
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