Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-kappaB binding activity and TNF-alpha secretion of T cells.

Preincubation with all anti-CD4 mAbs induced a significantly higher secretion of IL-10 than did the isotype control, not only after 24 h, but also after 48 hours (the latter increase did not reach statistical significance in the case of OX35).

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There was a highly significant negative correlation between the degree of the ConA-induced proliferation of CD4 + spleen T cells and the severity of the arthritis score, i.e. the lower the arthritis score, the higher the proliferation rate (Supplementary Fig. 3b ).

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