CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF-β signaling driving myelofibrosis.

This difference did not reach statistical significance ( p = 0.28), but the mean percentage of CCN2-positive megakaryocytes was significantly higher in myelofibrosis patients at diagnosis (63%) compared to post-transplant biopsies 22% [ 13 ].

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