Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells.

Sci Rep · 2024 · PMC11106297 · PMID 38769106

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

nearly significantno p-value reported

4 A), a nearly significant increase in FOXO1 protein (Fig. 4 B), and an increase in the mRNA of FOXO1-regulated transcriptional targets (Fig. 4 C).

also in 3,287 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.