Flare phenomenon visualized by ^99mTc-bone scintigraphy has prognostic value for patients with metastatic castration-resistant prostate cancer.

Gleason scores ≥ 9 and BSI positively correlated with borderline significance ( P = 0.053) without flare, compared with an apparently opposite trend with flare, although the difference did not reach significance.

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without and with flare, respectively However, even though PSA and ALP similarly changed, the difference did not reach statistical significance (Table 1 ).

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