Barely Significant
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The temporal association between adverse drug reactions and antirheumatic drugs utilisation in Western Australia: a retrospective study from real-world data (1995-2015).

Rheumatol Int · 2024 · PMC11108947 · PMID 38615313

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a clear trendno p-value reported
For biological DMARDs, a clear trend was not observed until 2004.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.