highly significantp < 0.0001
We found a highly significant lower frequency of SARS-CoV-2-specific TNF+CD4+ and CD8+ T cells ( p < 0.0001) correlated with increasing BMI category (Supplementary Table 11 ; ANOVA for general linear models with adjustment for covariates), as well as trends of lower SARS-CoV-2-specific IL-2+CD4+T cells and higher CRP ( p ≤ 0.014, q < 0.156).