High nitrate levels in skeletal muscle contribute to nitric oxide generation via a nitrate/nitrite reductive pathway in mice that lack the nNOS enzyme.

There was also a decreasing trend for nitrite levels in the skeletal muscle of nNOS−/− mice ( p = 0.0536) ( Figure 2D ) compared with WT mice with a −0.14 nmol/g tissue mean difference ( Supplementary Table S3 ).

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In LH-NO 3 - -treated WT mice, no significant changes in proteins associated with the nitrate/nitrite reductive pathway were detected in skeletal muscle ( Figures 9E, F ), while nNOS−/− mice treated with H-NO 3 - showed an increasing trend of XOR protein in skeletal muscle ( p = 0.0583, unpaired t -test) ( Figures 9A, B ).

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nNOS−/− mice treated with high nitrate showed a trend to increase XOR protein ( p = 0.0583, unpaired t -test), while nNOS−/− mice treated with low nitrate revealed a trend to increase sialin protein ( p = 0.0594, unpaired t -test).

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