Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia.

All exposures showed at least nominally significant associations with increased mortality, most significantly for SBP (HR, 1.04; 95% CI, 1.03-1.06; P = 1.9 × 10 −14 ); the association of WMH with mortality was no longer significant after adjusting for educational level or interim stroke status (eTables 9 and 10 in Supplement 1 ).

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In longitudinal individual-level analyses across 13 cohorts and biobanks with 157 698 participants, we observed a nonsignificant trend toward an association of larger WMH burden with incident all-cause dementia.

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