Investigating neonatal health risk variables through cell-type specific methylome-wide association studies.

First, in step A, we screened for the presence of nominally significant ( P < 0.05) cumulative effects of associated methylation sites in whole blood, to determine which factors and variables to include in the full-scale analysis, thereby minimizing false positive findings in the downstream analysis.

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Highly significant, cell-type specific, associations were detected for both common effect factors and for Apgar.

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