Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein 1 (FABP1) and FABP1 Binding Alters Drug Metabolism.

11 ) in the presence of FABP1 because the apparent K m for 4’-OH-diclofenac formation by CYP2C9 in the presence of hFABP1 (5.8 ± 1.5 μ M) only showed a trend for an increase ( P = 0.0011, 0.0729, 0.0416 for paired replicate experiments) when compared with in the absence of hFABP1 (1.4 ± 0.2 μ M) ( Supplemental Fig. 11 ; Table 2 ).

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