Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics.

There was a nominally significant association between endothelial cell loss and APOE ε4 homozygous genotype ( b = −9.6 × 10 −2 , SE = 4.3 × 10 −2 , P = 2.7 × 10 −2 ), which remained when restricting to only controls ( b = −9.9 × 10 −2 , SE = 4.7 × 10 −2 , P = 4.3 × 10 −2 ; n = 511), adjusting for baseline covariates.

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