Dental Pulp Stem Cells Modulate Inflammasome Pathway and Collagen Deposition of Dermal Fibroblasts.

As far as collagen genes are concerned, COL1A1 showed a trend towards an increase in fibroblasts co-cultured with DPSCs, but not in fibroblasts alone when treated with LPS.

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When treated with TNF-α + IL-1β, fibroblasts showed a decreasing trend in α-SMA expression together with a statistically significant decrease of fibronectin levels in fibroblasts co-cultured with DPSCs ( Figure 6 A).

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