Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations.

The clustering analysis based on network proteins showing increased levels in the NPM1-Ins patients showed that all except one of the patients with NPM1-Ins clustered together in the same main patient cluster, characterized by generally high levels of these proteins ( Figure 3 ); this difference in distribution of NPM1-Ins patients between the two main patient clusters is highly significant (Fisher’s exact test, p = 0.0002).

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Even though the frequency of AML relapse in first remission was slightly lower for patients with versus patients without NPM1-Ins (five out 13 versus six out of 12, respectively), this difference did not reach statistical significance.

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