Soluble Plasma Proteins of Tumor Necrosis Factor and Immunoglobulin Superfamilies Reveal New Insights into Immune Regulation in People with HIV and Opioid Use Disorder.

In contrast, in the HIV+ OP− Group 3, the unique Ig SF molecules compared to Group 4 were CTLA-4, Perforin, and PDL-2, of which PDL-2 and Perforin were negatively correlated with Ab responses, while CTLA-4 showed a trend.

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The differential expression of the top eight molecules ranked by median values in individual Groups 1–3 in comparison to Group 4 was highly significant.

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