Multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia.

15 demonstrated that children with a diagnosis of acute lymphoblastic leukemia and high LRP expression, as assessed by semiquantitative RT-PCR, showed a lower tendency to remain in first clinical remission, although this finding did not reach statistical significance. den Boer et al. 6 did not detect an adverse impact from LRP expression upon diagnosis, but only observed an increase in LRP expression in multiple relapses.

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