Dexamethasone, Glycemic Control, and Outcomes in Patients With Type 2 Diabetes Mellitus Undergoing Elective, Primary Total Joint Arthroplasty.

Discussion In our review of 1372 propensity matched patients with T2DM presenting for elective, primary TJA, we found that the administration of DEX was associated with significantly increased POD 0, POD 1, and POD 2 mean and maximum blood glucose as well as increased odds of being hyperglycemic on POD 0, and the odds of being hyperglycemic on POD 1 approaching borderline significance.

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In addition, patients receiving DEX, compared to patients not receiving DEX, were associated with a significant increase in hyperglycemia on POD 0 (OR: 4.0, 95% CI: 3.1-5.2), and a borderline significant increase in hyperglycemia on POD 1 (OR: 1.2, 95% CI: 0.9-1.5).

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