Consistent with the heterogeneity results, MR-PRESSO excluded outlier variants and estimated a corrected causal estimate that showed a marginally nonsignificant causal effect of GERD on T2D (OR: 1.11 [95% CI: 0.99–1.23], P = 9.00 × 10 −2 ) [Fig. 4 and Supplementary Data 4 ].
Similarly, we found a highly significant global genetic correlation between T2D and PGM (Table 2 ).
We found that many of the identified loci (significant or nominally significant) were completely shared (that is, ‘the 95% confidence interval for the explained variance included 1’ 42 ) by T2D and GI disorders (Table 3 ), further supporting evidence of their shared genetic basis.