Decreasing microtubule detyrosination modulates Nav1.5 subcellular distribution and restores sodium current in mdx cardiomyocytes.

These immunofluorescence experiments revealed a statistically significant increase of detyrosinated α-tubulin in mdx CMs compared to WT CMs, a clear trend towards an increase in total α-tubulin, in line with previous findings showing an increase in density of the MT network, 6 , 7 , 10 , 11 , 14 , 15 and a significant increase in the ratio of detyrosinated α-tubulin on total α-tubulin ( Figure 1 B ).

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