Barely Significant
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Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.

Sci Rep · 2024 · PMC11137013 · PMID 38811759

Europe PMCDOI
2
hedged sentences
0.0001
closest p · 0.0× alpha
0.0560
boldest claim

The sentences

highly significantP < 0.0001actually significant
Segregating the mice by sex exposed a 4.75-fold increase of Wnt signaling activity in male LRRK2 KO mice and a 4.66-fold increase of Wnt signaling activity in male LRRK2 G2019S KI mice with both effects being highly significant ( P < 0.0001; Fig. 2 B).

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showed a trendP = 0.056so close (0.05 < p ≤ 0.1)
BDNF protein levels showed a trend towards upregulation ( P = 0.056), while expression levels for Bdnf were significantly downregulated in the cortex of LRRK2 KO mice (Fig. 7 A 1 and B 2 ).

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