Variability in SOD1-associated amyotrophic lateral sclerosis: geographic patterns, clinical heterogeneity, molecular alterations, and therapeutic implications.

Although this study identified a decreasing trend in enzymatic activity, a definitive association between this specific deletion and ALS pathogenesis was not conclusive.

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Linear models for both heterogeneous and homogeneous D91A consistently showed a negative trend, indicating that an earlier age of onset is associated with an extended disease duration among individuals with this variant.

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