Loci cg06256735 and cg15815843 in the MFAP5 gene regulatory regions are hypomethylated in varicose veins apparently due to active demethylation.

For the cg15815843 locus ( Figure 4 E) gender tended to have an effect on the 5hmC level in NV ( R = 0.715, P ( R ) = 0.117), height and CEAP class – in VV ( R = 0.917, P ( R ) = 0.068) but all of them did not reach statistical significance of R coefficient.

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