The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use.

80 , 86 , 98 Lofepramine also showed a tendency to increase the risk of stroke compared with no antidepressant drug 98 and was associated with relatively higher relative risk than other TCAs assessed; however, this difference did not reach statistical significance. 80 , 98 It should be noted, nonetheless, that statistical association may not be causative (there may be confounding factors) and that the absence of statistical association does not preclude association (there may have been insufficient statistical power to reveal differences).

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