Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney.

In addition, patients with lower CCN1/creatinine levels (defined as less than average value among this group of patients) showed a trend of having lower eGFR and older age, and they were more likely to progress to end-stage kidney disease (data not shown).

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Unbiased tissue specificity analysis using TissueEnrich ( 22 ) and the GTEx Multi Gene Query platform assigned a highly significant brain tissue identity to MD cells, while the transcriptome of control kidney cells showed high ranking of kidney specificity and no expression in brain ( Supplemental Figure 3A ).

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