The total number of CREs with nominally significant differential signal P -values has less effect on the total number of significant DegCre associations ( Supplemental Fig. 1C ).
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Probabilistic association of differentially expressed genes with <i>cis</i>-regulatory elements.
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The sentences
Thus, if bins are too small and harbor only highly significant or only insignificant P -values, then true pairs cannot be distinguished from the background.