Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy.

The Capan-1 cell line, which has a BRCA2 mutation [ 23 ], showed a trend towards greater resistance to panobinostat compared with the BxPC-3 and PL45 cells ( Figure 1A ); the three cell lines showed similar sensitivity to vorinostat ( Figure 1B ).

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