Beyond the Gut: A Systematic Review and Meta-analysis of Advanced Therapies for Inflammatory Bowel Disease-associated Extraintestinal Manifestations.

Studies comparing VDZ and UST directly also observed that patients on VDZ experienced a higher occurrence of deteriorating pre-existing rheumatic EIMs than patients receiving VDZ, although the difference did not reach statistical significance. 63 Previous studies have provided evidence that UST may be beneficial for peripheral arthritis in IBD, but not for axial SpA, 18 although the IL23/Th17 pathway is also involved in the pathogenesis of axial SpA. 63 Furthermore, TOFA Phase 3 trials are under way to establish its safety and efficacy in axial SpA.

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