Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.

4F ); an increasing trend was observed in female Apoo/Ldlr dKO mice (Fig. 4G ).

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Consistently, following the restoration of CYB5R3, Apoo −/− mice showed a strong trend toward increased fecal cholesterol excretion, being very similar to that in Apoo +/+ mice (Fig. 7J ).

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