nearly significantp = 0.0575
The layering of medical countermeasures resulted in statistically significant synergy in female mice immunized with P:Δ caf1 B:rF1-V ( p = 0.0017) or nearly significant synergy in female mice immunized with P:Δ yopD /Δ caf1 B:rF1-V ( p = 0.0575), using the Bliss independence model to calculate synergy scores ( 62 ).