Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers.

However, a pronounced trend of hypomethylation (Δ methylation > 0.1) in PMDs and a minor shift toward hypomethylation (Δ methylation ≤ 0.1) was found in HMDs for S2 iCCAs, respectively (Supplementary Fig.

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S4C), which inversely showed a significant trend toward hypermethylation in the majority of iCCAs when compared with normal controls, further proving the necessity of WGBS for an accurate evaluation of iCCA DNA methylation.

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