The changing epidemiology of <i>Clostridioides difficile</i> infection and the NAP1/027 strain in two Québec hospitals: a 17-year time-series study.

Antimicrob Steward Healthc Epidemiol · 2024 · PMC11149029 · PMID 38836044

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a decreasing trendno p-value reported

9 Recent studies from the United States demonstrate a decreasing trend for HA-CDI in the last decade with a reduced prevalence of the NAP1/027 strain. 10 , 11 Antibiotic use is the major risk factor associated with CDI.

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did not reach statistical significanceno p-value reported

There was a trend in decreased fluoroquinolone utilization over time with the decrease in proportion of isolates of the NAP1/027 strain at our second study hospital, but this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.