A host-microbial metabolite interaction gut-on-a-chip model of the adult human intestine demonstrates beneficial effects upon inulin treatment of gut microbiome.

Claudin-1 and Claudin-2 expression were also both non-significantly higher in the segments exposed to the inulin-treated supernatant, whereas zonulin-1 showed a decreasing trend [ Figure 5A ].

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SCFA supplementation also showed a trend to increase claudin-2 expression, but did not alter mRNA levels of claudin-1 or zonulin-1, indicating that other components than SCFA in the inulin-treated i-screen supernatant are likely at play in regulating the expression of these two genes.

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