a significant trendp <0.0001
Another type of interest is emm 12, which did not demonstrate a significant trend from 2018 to 2022; however, emm 12 decreased significantly from 4.5% (n=145) in 2018 to 1.0% (n=22) in 2021 ( p <0.0001), before significantly rising back up to 5.8% (n=151) in 2022 ( p <0.0001).