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Cellular pharmacokinetic of methotrexate and its modulation by folylpolyglutamate synthetase and γ-glutamyl hydrolase in tumor cells.

PLoS One · 2024 · PMC11149982 · PMID 38833640

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showed a trendno p-value reported
The intracellular concentration of MTX-PG 2-7 showed a trend similar to that of cell inhibition rate.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.