Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer's disease pathology progression.

However, we detected an eQTL signal tagged by rs11235459 which was nominally significant in both CSF pTau GWAS ( p = 5.4 × 10 –4 , OR = 0.93 [95% CI 0.89–0.97]) and INPPL1 ROSMAP DLPFC eQTL catalogue ( p = 9.1 × 10 –4 , beta = -0.06 [95% CI −0.02 to −0.09]) (Fig. 9 b).

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