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Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022.

J Atheroscler Thromb · 2024 · PMC11150976 · PMID 38123343

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an increasing trendno p-value reported
Over the past 10 years, this proportion remained unchanged in men and showed an increasing trend in women.

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showed a trendno p-value reported
The HIJ-PROPER study 341) of ACS did not statistically prove the benefit of active LDL-C lowering therapy with ezetimibe compared to pitavastatin alone, but showed a trend toward the reduction of ASCVD, suggesting that the management of LDL-C in secondary prevention is also “the lower, the better.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.