Effect of non-invasive spinal cord stimulation in unmedicated adults with major depressive disorder: a pilot randomized controlled trial and induced current flow pattern.

Secondary and exploratory outcome Clinical measures Categorical response rate differences between the intervention groups according to MADRS score did not reach statistical significance for partial response ( p = 0.08), response ( p = 0.36), or remission ( p = 0.34) criteria (Supplementary Table 2 ).

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A statistical trend in the same direction was observed for “pessimistic thoughts” item (−0.8 ± 0.5 vs. −1.9 ± 0.4, 0.094), as well as week-8 clinical global impression-improvement (CGI-I) scale scores (2.0 ± 0.3 vs. 1.3 ± 0.3, p = 0.091).

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