Longitudinal analysis of circulating tumor cell numbers improves tracking metastatic breast cancer progression.

Survival analysis confirms the importance of more than 5 CTCs in the sample Kaplan–Meier survival analysis and landmark analysis for follow-up collections indicated that although CTCs presence/absence in the first collection was not significant for PFS and OS, detection of ≥ 5 CTCs was identified to be significant for OS (log-rank test p < 0.05) and a strong trend for PFS was also observed (log-rank test p = 0.0578) (Fig. 2 A,B).

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