a trend toward significancep -value = 0.087
Although the correlation was not statistically significant, we observed a trend toward significance, indicating that hypermethylation was associated with THBS2 silencing (r = -0.75, p -value = 0.087).
Although the correlation was not statistically significant, we observed a trend toward significance, indicating that hypermethylation was associated with THBS2 silencing (r = -0.75, p -value = 0.087).
Additionally, we checked the methylation levels by mRS levels (from 0 to 5–6) of CpGs that were nominally significant at both stages to infer whether these DMPs were ordinally associated with mRS.
We also found one DMR that was marginally significant (Q-value = 0.052), which was annotated to the gene Homeobox A5 ( HOXA5 , 8 CpGs).