Thus, there was an overall trend toward lower levels of mitochondrial proteins in the BORC-KO axons, although these reductions were less dramatic than those of the corresponding mRNAs (Supplementary Tables 1 and 2 ).
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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration.
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The sentences
We observed that the levels of the mitochondrial complex I–V proteins NDUFS1, SDHA, CYCS, COXIV and ATP5A were significantly reduced in axons from BORCS5-KO and BORCS7-KO i3Neurons, with only two exceptions in which the reductions did not reach statistical significance (NDUFS1 and CYCS in BORCS7-KO cells) (Fig. 6a,b ).