<i>Bacillus</i> coagulans and <i>Clostridium</i> butyricum synergistically alleviate depression in a chronic unpredictable mild stress mouse model through altering gut microbiota and prefrontal cortex gene expression.

After five weeks of treatment, sucrose preference did not show a significant difference among the six groups in SPT ( Figure 1B ), though the CUMS group showed a decreasing trend relative to CON and the HIGH group showed an increasing trend, which indicated that neither CUMS stimulation nor the probiotics or fluoxetine influenced anhedonia.

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Although showing no significance, the probiotics showed a trend in increasing the abundance of B . pseudolongum (0.76%–1.7%).

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