Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color.

Including rs74653330 (p.Ala481Thr), a missense lead variant in OCA2 , a total of 12 independent nonsynonymous variants associated with skin color traits were identified in the GWAS (Supplementary Data 5 ): 1 in a previously unreported locus, 9 in previously reported loci, and 2 in nominally significant loci (top variants of 2 loci did not pass the genome-wide significance level, P < 5.0 × 10 −8 ).

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