Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader.

Statistical significance was determined based on P values, with * P < 0.05 considered statistically significant, ** P < 0.01 considered highly significant, and *** P < 0.001 considered extremely significant.

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Furthermore, ChIP-qPCR analysis revealed a slight increase in the enrichment of H3K18la with Dux OE, although this increase did not reach statistical significance (Figure 4G ).

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