Gene expression analysis for the alpha and beta-globin loci At the alpha globin coding locus, a strong trend of down-regulation during flight was noted for the JAXA astronauts for the HBA1 and HBA2 genes (for the duration of readings from 5 days after launch to 60 days after launch), followed by an observed up-regulation in expression immediately upon return to ground, even higher than expression recorded pre-flight.
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