Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations.

The TBK1 E232Q mutant also slightly increased the OPTN-TBK1 complex formation, and the TBK1 I37T mutant marginally decreased the OPTN-TBK1 binding, but these effects did not reach statistical significance (Fig. 4 B, E).

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